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The Warsaw Voice » The Polish Science Voice » November 25, 2011
The Polish Science Voice
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Mossakowski Medical Research Centre
November 25, 2011   
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The Mossakowski Medical Research Centre in Warsaw is the largest institute of the Sixth Department of Medical Sciences at the Polish Academy of Sciences. The institute pursues both experimental and clinical research.

The research topics, strictly related to medicine, focus on experimental physiology and pathophysiology, experimental pharmacology and therapy, in addition to clinical problems. Studies into the genetic causes of Alzheimer’s, other neurodegenerative diseases and neuromuscular diseases make up an important part of the center’s research. Research into the risk factors and mechanisms of brain damage caused by inadequate blood and oxygen supply, including studies into immunological factors, make up another important area of research conducted at the center.

Neurobiological studies are complemented by research into the pathophysiology of the kidney, physiology of exercise, physiology of breathing, immunological response mechanisms, transplant rejection mechanisms and molecular basis of thyroid diseases. Studies of methods for diagnosing brain tumors and synthesizing new pharmacologically active chemicals, including analgesic peptides and nucleosides selectively killing cancer cells, and research into umbilical cord blood stem cells, which can be transformed into nerve cells, are especially promising and may find practical application in the future.

The centre plans to set up an Experimental Medicine Centre (CMD) that will be composed of four laboratories:
- a laboratory breeding genetically modified animals;
- a laboratory for magnetic resonance imaging on small animals;
- a chemical synthesis laboratory;
- and a toxicological research laboratory.

The laboratories will be involved in the pilot-scale production of peptides and molecular agents with potential for therapeutic application to be used in preclinical research and clinical trials. The researchers will also examine the influence of these agents on cells, through in vitro tests, and on organisms, through in vivo tests, as well as their therapeutic activity in standardized models of diseases—in particular neurodegenerative diseases such as Alzheimer’s and Parkinson’s, in addition to stroke and hypoglycemic shock—and in models of tumors of the nervous system, including gliomas of the brain implanted in mice and rats.

Also conducted will be ADME research, in which scientists will be examining the biodistribution and biotransformation of the pharmaceutical compounds in lab animals. Additionally, researchers will be working to develop new contrast agents for magnetic resonance and Doppler ultrasound imaging techniques, especially contrast agents for molecular imaging. The centre will also deal with determining the toxicity and carcinogenicity of chemical substances, in particular pharmacologically active compounds.

The CePT project has enabled the Mossakowski Medical Research Centre to acquire funding for setting up state-of-the-art laboratories.

The laboratory for magnetic resonance imaging on small animals will offer new research prospects by creating conditions for reducing and optimizing the use of lab animals.

Resonance techniques enable a non-invasive insight into the structure and functions of the body, creating conditions for the intravital observation of disease processes.

The laboratories to be established as part of the Experimental Medicine Centre will create conditions for collaboration with both Polish and foreign companies in the area of preclinical research into new drugs, pharmaceutical forms and treatment methods, and in preparing new drugs for clinical trials. The laboratories, which will be built with the use of CePT funding, will be open to other research institutions, especially those taking part in the CePT project.
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